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Aging

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Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice

Overview of attention for article published in Aging, March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 1,090)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
52 news outlets
blogs
1 blog
twitter
1 tweeter
facebook
2 Facebook pages
video
1 video uploader

Citations

dimensions_citation
36 Dimensions

Readers on

mendeley
48 Mendeley
Title
Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice
Published in
Aging, March 2017
DOI 10.18632/aging.101206
Pubmed ID
Authors

Marina P. Antoch, Michelle Wrobel, Karen K. Kuropatwinski, Ilya Gitlin, Katerina I. Leonova, Ilia Toshkov, Anatoli S. Gleiberman, Alan D. Hutson, Olga B. Chernova, Andrei V. Gudkov

Abstract

The development of healthspan-extending pharmaceuticals requires quantitative estimation of age-related progressive physiological decline. In humans, individual health status can be quantitatively assessed by means of a frailty index (FI), a parameter which reflects the scale of accumulation of age-related deficits. However, adaptation of this methodology to animal models is a challenging task since it includes multiple subjective parameters. Here we report a development of a quantitative non-invasive procedure to estimate biological age of an individual animal by creating physiological frailty index (PFI). We demonstrated the dynamics of PFI increase during chronological aging of male and female NIH Swiss mice. We also demonstrated acceleration of growth of PFI in animals placed on a high fat diet, reflecting aging acceleration by obesity and provide a tool for its quantitative assessment. Additionally, we showed that PFI could reveal anti-aging effect of mTOR inhibitor rapatar (bioavailable formulation of rapamycin) prior to registration of its effects on longevity. PFI revealed substantial sex-related differences in normal chronological aging and in the efficacy of detrimental (high fat diet) or beneficial (rapatar) aging modulatory factors. Together, these data introduce PFI as a reliable, non-invasive, quantitative tool suitable for testing potential anti-aging pharmaceuticals in pre-clinical studies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Czechia 1 2%
Unknown 46 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 29%
Student > Ph. D. Student 7 15%
Student > Master 6 13%
Other 5 10%
Student > Doctoral Student 4 8%
Other 5 10%
Unknown 7 15%
Readers by discipline Count As %
Medicine and Dentistry 9 19%
Agricultural and Biological Sciences 9 19%
Biochemistry, Genetics and Molecular Biology 7 15%
Business, Management and Accounting 3 6%
Nursing and Health Professions 2 4%
Other 10 21%
Unknown 8 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 416. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2018.
All research outputs
#23,938
of 13,599,972 outputs
Outputs from Aging
#5
of 1,090 outputs
Outputs of similar age
#1,301
of 262,494 outputs
Outputs of similar age from Aging
#2
of 36 outputs
Altmetric has tracked 13,599,972 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,090 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,494 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.