| Title |
Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1
|
|---|---|
| Published in |
Aging, February 2017
|
| DOI | 10.18632/aging.101174 |
| Pubmed ID | |
| Authors |
Irina G. Shabalina, Mikhail Yu. Vyssokikh, Natalia Gibanova, Robert I. Csikasz, Daniel Edgar, Anne Hallden-Waldemarson, Zinaida Rozhdestvenskaya, Lora E. Bakeeva, Valeria B. Vays, Antonina V. Pustovidko, Maxim V. Skulachev, Barbara Cannon, Vladimir P. Skulachev, Jan Nedergaard |
| Abstract |
MtDNA mutator mice exhibit marked features of premature aging. We find that these mice treated from age of ≈100 days with the mitochondria-targeted antioxidant SkQ1 showed a delayed appearance of traits of aging such as kyphosis, alopecia, lowering of body temperature, body weight loss, as well as ameliorated heart, kidney and liver pathologies. These effects of SkQ1 are suggested to be related to an alleviation of the effects of an enhanced reactive oxygen species (ROS) level in mtDNA mutator mice: the increased mitochondrial ROS released due to mitochondrial mutations probably interact with polyunsaturated fatty acids in cardiolipin, releasing malondialdehyde and 4-hydroxynonenal that form protein adducts and thus diminishes mitochondrial functions. SkQ1 counteracts this as it scavenges mitochondrial ROS. As the results, the normal mitochondrial ultrastructure is preserved in liver and heart; the phosphorylation capacity of skeletal muscle mitochondria as well as the thermogenic capacity of brown adipose tissue is also improved. The SkQ1-treated mice live significantly longer (335 versus 290 days). These data may be relevant in relation to treatment of mitochondrial diseases particularly and the process of aging in general. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 17% |
| Canada | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 1% |
| Unknown | 67 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 22% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Bachelor | 8 | 12% |
| Student > Master | 8 | 12% |
| Professor > Associate Professor | 6 | 9% |
| Other | 10 | 15% |
| Unknown | 12 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 29% |
| Agricultural and Biological Sciences | 14 | 21% |
| Medicine and Dentistry | 6 | 9% |
| Neuroscience | 4 | 6% |
| Environmental Science | 2 | 3% |
| Other | 7 | 10% |
| Unknown | 15 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 629. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2023.
All research outputs
#32,649
of 24,334,327 outputs
Outputs from Aging
#6
of 3,858 outputs
Outputs of similar age
#813
of 462,417 outputs
Outputs of similar age from Aging
#2
of 36 outputs
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